Executive Director, DMPK
Company: Nimbus Therapeutics, Inc.
Location: Boston
Posted on: May 3, 2024
Job Description:
Nimbus has an outstanding opportunity for an exceptional
Executive Director, DMPK to join our team. This role will serve as
the function head, applying subject matter expertise in absorption,
distribution, metabolism, and excretion (ADME), pharmacokinetics,
and pharmacodynamics, along with effective team management skills,
to drive the strategy and execution of our clinical development and
pre-clinical programs. You will report to our Senior Vice President
of Nonclinical Sciences.In this role, you will:
- Design and execute preclinical studies to understand the
pharmacokinetics (PK) and absorption, metabolism, distribution, and
excretion (ADME) of drug candidates that support drug discovery,
preclinical and clinical development
- Responsible for the analysis, interpretation, integration and
reporting of preclinical DMPK data generated both internally and
with external collaborators
- Represent DMPK as the subject matter expert to project
teams
- Provide leadership and management support for nonclinical DMPK
that can build and inspire our teams and drive collaboration and
innovation
- Establish effective relationships with CROs, consultants, and
internal team members to develop and qualify various analytical and
bioanalytical methods.
- Design, contract and manage CRO in the conduct of in vitro / in
vivo ADME studies. Review study protocols and reports, interpret
and communicate results
- Prepare strategic and scientifically sophisticated ADME
strategies that meet regulatory requirements and program goals
- Author, review and approve scientific reports that support
regulatory documents including INDs, CTAs, and NDA filings.
- Partner with and support Toxicology, Research, Clinical,
Regulatory, Project Management and other departments
- Provide leadership and management support for nonclinical DMPK
that can build and inspire our teams and drive collaboration and
innovationThese Qualifications Will Help This Role Be Successful:
- PhD in Pharmacokinetics, Pharmacology, Pharmaceutical Science
or other relevant field with 15+ years of experience in the
biopharmaceutical industry
- Strong knowledge of small-molecule drug metabolism, ADME
concepts, pharmacokinetics, pharmacodynamic and bioanalytical
principles
- Track record of success with clinical development phases
- Ability and Interest in leading dynamic, multi-disciplined
project teams
- Prior experience with regulatory submission (e.g., IND, NDA
and/or BLA) preferred
- Working knowledge in various modeling techniques and programing
preferred
- Excellent verbal and written communication and organizational
skills required with experience working on cross functional
teams
- Ability to navigate, problem-solve, execute, and lead in a
dynamic, fast-paced and evolving environment A Snapshot of Nimbus
Our S cience At Nimbus, we design breakthrough medicines. Utilizing
our powerful structure-based drug discovery engine, we create
potent and selective small molecule compounds targeting proteins
that are known to be fundamental drivers of pathology in highly
prevalent human diseases and which have proven difficult for other
drug makers to tackle. With a decade-plus track record of success,
we've built a world-class team in both computationally driven drug
discovery and early clinical development while continuing to move
the needle for patients. Our C ulture Nimbus is a close-knit
company (our employees are Nimbi, if you are curious!) that values
a fast-paced, entrepreneurial , intellectual- stimulating, and
collaborative environment. We live by o ur Core Values: Integrity,
a Passion for Excellence, Teamwork, and Authentic Communication and
strive to build a community where we bring out the best in each
other professionally and personally. Our Company Founded in 2009,
Nimbus is a private , growing biotechnology company headquartered
in Boston, Massachusetts. Learn more about us by going to
www.nimbustx.com Join Nimbus. We are making a difference and you
can too. At Nimbus, we believe our diversity of backgrounds and
experiences strengthens our community and our ability to design
breakthrough medicines. We prioritize creating an inclusive,
welcoming culture that promotes our core values and encourages
every Nimbi to bring their whole selves to their work. Nimbus is
proud to be an equal opportunity employer. We value and celebrate
all our employees and recognize that our diversity and inclusion
are keys to our success. Nimbus is committed to providing equal
opportunity for all employees and applicants without regard to
race, color, gender, gender identity, sexual orientation, age,
religion, national or ethnic origin, disability, protected veteran
status or any other basis protected by applicable law. Nimbus does
not accept unsolicited resumes from any source other than directly
from candidates.
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Keywords: Nimbus Therapeutics, Inc., Manchester , Executive Director, DMPK, Executive , Boston, New Hampshire
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